2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W007803
    Boc-NH-C4-Br 164365-88-2 98.0%
    Boc-NH-C4-Br is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-C4-Br
  • HY-117009
    Bis-PEG9-NHS ester 1008402-79-6 98.0%
    Bis-PEG9-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG9-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Bis-PEG9-NHS ester
  • HY-W096093
    2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride 1035373-85-3 99.90%
    2-(2-(6-chlorohexyloxy)ethoxy)ethanamine (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride
  • HY-140212
    Azido-PEG1-amine 464190-91-8 98.0%
    Azido-PEG1-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG1-amine
  • HY-W042255
    tert-Butyl 3-bromopropanoate 55666-43-8 99.90%
    tert-Butyl 3-bromopropanoate is a PROTAC linker that can be used in the synthesis of PROTACs.
    tert-Butyl 3-bromopropanoate
  • HY-42490
    N3-PEG3-CH2CH2COOH 1056024-94-2 98.0%
    N3-PEG3-CH2CH2COOH a PEG-based PROTAC linker can be used in the synthesis of BI-3663 (HY-111546), BI-4216 and BI-0319. Azido-PEG3-acid is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-PEG3-CH2CH2COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N3-PEG3-CH2CH2COOH
  • HY-W001056
    3-(Methoxycarbonyl)bicyclo[1.1.1]pentane-1-carboxylic acid 83249-10-9 99.72%
    3-(Methoxycarbonyl)bicyclo[1.1.1]pentane-1-carboxylic acid is a PROTAC linker that can be used in the synthesis of PROTACs.
    3-(Methoxycarbonyl)bicyclo[1.1.1]pentane-1-carboxylic acid
  • HY-W010642
    Pent-4-yn-1-ol 5390-04-5 99.59%
    Pent-4-yn-1-ol is a PROTAC linker. Pent-4-yn-1-ol can be used to synthesize PROTAC molecules (e.g. RD-23 (HY-168867)).
    Pent-4-yn-1-ol
  • HY-130291
    Biotin-PEG3-NHS ester 1253286-56-4 99.35%
    Biotin-PEG3-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
    Biotin-PEG3-NHS ester
  • HY-W015300
    Suberic acid 505-48-6 98.0%
    Suberic acid (Octanedioic acid) is an orally active crystalline dibasic acid. Suberic acid activates the Akt signaling pathway and regulates the expression of molecules related to the TGF-β and MAPK signaling pathways. Suberic acid inhibits skin dryness.
    Suberic acid
  • HY-140208
    2,2-Oxybis(ethylamine) 2752-17-2 99.96%
    22-Oxybis(ethylamine) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    2,2-Oxybis(ethylamine)
  • HY-W002926
    tert-Butyl N-[4-(aminomethyl)phenyl]carbamate 220298-96-4 98.94%
    tert-Butyl N-[4-(aminomethyl)phenyl]carbamate is a PROTAC linker that can be used in the synthesis of PROTACs.
    tert-Butyl N-[4-(aminomethyl)phenyl]carbamate
  • HY-69260
    tert-Butyl 4-formylpiperidine-1-carboxylate 137076-22-3 99.54%
    tert-Butyl 4-formylpiperidine-1-carboxylate is a PROTAC linker and can be used in the synthesis of PROTAC BRM/BRG1 degrader-3 (HY-168251).
    tert-Butyl 4-formylpiperidine-1-carboxylate
  • HY-Y0925
    5-Hexynoic acid 53293-00-8
    5-Hexynoic acid (Hex-5-ynoic acid) is an alkynoic acid. 5-Hexynoic acid serves as a drug intermediate for the synthesis of 3-alkoxy-2-cyclohexenone.
    5-Hexynoic acid
  • HY-140453
    Azido-PEG6-acid 361189-66-4 99.91%
    Azido-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG6-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG6-acid
  • HY-126889
    Bis-PEG5-NHS ester 756526-03-1 99.83%
    Bis-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Bis-PEG5-NHS ester
  • HY-141336
    α-Lipoic acid-NHS 40846-94-4 98.0%
    α-Lipoic acid-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    α-Lipoic acid-NHS
  • HY-33462
    6-Amino-1-hexanethiol hydrochloride 31098-40-5 98.0%
    6-Amino-1-hexanethiol hydrochloride is a PROTAC linker that can be used in the synthesis of PROTACs.
    6-Amino-1-hexanethiol hydrochloride
  • HY-140273
    DBCO-PEG8-NHS ester 2553412-88-5 98.34%
    DBCO-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG8-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG8-NHS ester
  • HY-W012241
    Dodecanedioic acid 693-23-2 98.0%
    Dodecanedioic acid is an orally active straight-chain dicarboxylic acid. As an alternative energy substrate between lipids and carbohydrates, Dodecanedioic acid can be rapidly oxidized during exercise, reducing muscle fatigue without stimulating insulin secretion. Dodecanedioic acid also exhibits blood glucose-lowering activity in non-insulin-dependent diabetes mellitus.
    Dodecanedioic acid
PROTAC Linkers Isoform Comparison

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